IRIS - Res&Arch Institutional Research Information System - Research & Archive

GIOIELLO, ANTIMO
 Distribuzione geografica
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Continente #
NA - Nord America 3.588
EU - Europa 2.687
AS - Asia 1.048
Continente sconosciuto - Info sul continente non disponibili 6
SA - Sud America 6
OC - Oceania 4
AF - Africa 2
Totale 7.341
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Nazione #
US - Stati Uniti d'America 3.577
IE - Irlanda 704
IT - Italia 601
SG - Singapore 481
UA - Ucraina 386
SE - Svezia 317
HK - Hong Kong 233
DE - Germania 143
CN - Cina 142
FI - Finlandia 137
RU - Federazione Russa 130
VN - Vietnam 100
GB - Regno Unito 67
FR - Francia 47
CH - Svizzera 34
TR - Turchia 33
BE - Belgio 22
KR - Corea 21
CZ - Repubblica Ceca 20
ES - Italia 14
PL - Polonia 14
NL - Olanda 13
AT - Austria 11
GR - Grecia 9
IN - India 8
MX - Messico 8
JP - Giappone 7
LB - Libano 7
UZ - Uzbekistan 7
EU - Europa 6
BG - Bulgaria 5
RO - Romania 5
TW - Taiwan 4
CA - Canada 3
AU - Australia 2
BR - Brasile 2
CO - Colombia 2
NO - Norvegia 2
NZ - Nuova Zelanda 2
SK - Slovacchia (Repubblica Slovacca) 2
AE - Emirati Arabi Uniti 1
AF - Afghanistan, Repubblica islamica di 1
AR - Argentina 1
BD - Bangladesh 1
CL - Cile 1
EG - Egitto 1
HU - Ungheria 1
ID - Indonesia 1
LV - Lettonia 1
ME - Montenegro 1
NG - Nigeria 1
SI - Slovenia 1
TH - Thailandia 1
Totale 7.341
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Città #
Dublin 704
Chandler 673
San Mateo 397
Singapore 367
Boardman 233
Hong Kong 230
Perugia 210
Jacksonville 200
Santa Clara 198
Medford 169
Princeton 166
Altamura 121
Ann Arbor 121
Wilmington 118
Andover 99
Dong Ket 99
Lawrence 98
Beijing 59
Redmond 56
Des Moines 51
Saint Petersburg 46
Ashburn 37
Izmir 33
Norwalk 31
Woodbridge 30
Brussels 22
Los Angeles 22
San Paolo di Civitate 21
Seoul 21
Redwood City 18
Rome 18
Falls Church 17
Dallas 16
Munich 15
Helsinki 14
Brno 12
Fremont 12
New York 12
Bologna 11
Leeds 11
Dearborn 10
Saronno 10
Shanghai 10
Spoleto 10
Moscow 9
Frankfurt Am Main 7
Houston 7
Arroyo de la Encomienda 6
Kraków 6
Lausanne 6
Misano Adriatico 6
Olomouc 6
San Giustino 6
Auburn Hills 5
Chicago 5
Den Haag 5
Florence 4
Granada 4
Iesi 4
Lappeenranta 4
Macerata 4
Mcallen 4
Milan 4
Nanning 4
Simi Valley 4
State College 4
Terni 4
Timisoara 4
Aprilia 3
Cambridge 3
Civitanova Marche 3
Foligno 3
Groningen 3
Guangzhou 3
Hanover 3
London 3
Madrid 3
Padova 3
Pune 3
Salerno 3
Tokyo 3
Torino 3
Zero Branco 3
Battipaglia 2
Bellagio 2
Bodø 2
Bratislava 2
Cartagena 2
Coalville 2
Detroit 2
Fairfield 2
Fort Worth 2
Hangzhou 2
Irapuato 2
Kaohsiung 2
Menlo Park 2
Nagold 2
Nagoya 2
Nanjing 2
Naples 2
Totale 5.029
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Nome #
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 120
Achiral-chiral two-dimensional chromatography of free amino acids in milk: A promising tool for detecting different levels of mastitis in cows 94
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 93
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells 92
Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors 90
Analisi HPLC/ELSD di Acidi Biliari Amidati: un Approccio Efficace Per Assistere Processi Sintetici a Flusso Continuo 84
Vitamin E: metabolism and molecular aspects 78
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 76
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 75
New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compunds 73
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 72
Side-chain Modified Bile Acids: Chromatographic Separation of 23-Methyl Epimers 72
Indium triflate catalyzed reaction of diisopropyl diazomethylphophonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates 72
Selenium catalyzed oxacyclization of alkenoic acids and alkenols 72
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 70
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 69
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 69
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 69
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 65
Targeting the FXR nuclear receptor through a virtual screening approach 64
Selective continuous flow synthesis of hydroxy lactones from alkenoic acids 64
LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum 63
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 62
Continuous Flow Synthesis and Enzymatic Resolution of 3-Hydroxy-ɣ-Butyrolactone (3-BHL): A Key Building Block for Synthesis and Drugs 62
A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation 61
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor 61
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione 61
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 60
Chromatographic separation of free dafachronic acid epimers with a novel triazole click quinidine-based chiral stationary phase 60
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 60
Development of a Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate: A Powered Entry into Steroids from Plants 59
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 58
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 58
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 57
Tandem Mass Spectrometric Determination of Atypical 3-Hydroxy-Δ5-Bile Acids in Patients with 3-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response 57
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 57
BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects 57
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 56
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 56
HPLC/ELSD analysis of amidated bile acids: an effective and rapid way to assist continuous flow chemistry processes 56
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 56
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 55
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 55
Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone 54
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 54
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 54
Chromatographic evaluation of the 25-(R,S)-methyl-bishomo-hyodeoxycholic acid epimers 53
The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology 53
BF3•Et2O-Induced Decomposition of Ethyl 2-Diazo-3-hydroxy-3,3-diarylpropanoates in Acetonitrile: A Novel Approach to 2,3-Diaryl β-Enamino Ester Derivatives 52
Novel body modified bile acid derivatives as TGR5 modulators 51
Progress and challenges of selective Farnesoid X Receptor modulation 51
Multiclass screening method to detect more than fifty banned substances in bovine bile and urine 51
Improved chromatographic diastereoresolution of cyclopropyl dafachronic acid derivatives using chiral anion exchangers 51
Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23-and 6,23-Alkyl-Sobstituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5 49
Divergent and stereoselective synthesis of dafachronic acids 49
ATYPICAL BILE ACIDS AS CHEMICAL PROBES FOR DIAGNOSIS AND THERAPHY MONITORING OF PROGRESSIVE CHOLESTATIC LIVER DISEASE IN HSD3B7 PATIENTS 49
Flow Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles as Excipient for Spray-Drying Formulations 49
Mesofluidic Flash Nanoprecipitation of D-Leucine Particles as Excipient in Powders for Inhalation 49
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis 49
TGR5-mediated bile acid sensing controls glucose homeostasis. 48
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts 48
New potent and selective FXR agonists: design, synthesis and modeling of norcholanylamine derivatives 48
Unraveling the Molecular Basis for DAF -12 Activation: Diastereoselective Synthesis and SAR Studies of Dafachronic Acid Derivatives 48
Application of Untargeted and Targeted Metabolomics to the Study of Liver Disease Caused by a Deficiency in HSD3B7-diagnosis and Response to Therapy 48
Flow nanoprecipitation of size-controlled d-leucine nanoparticles for spray-drying formulations 48
Discovery and Structure–Activity Relationships of Novel ssDAF-12 Receptor Modulators 47
Fast chromatographic determination of the bile salt critical micellar concentration 47
Development and identification of new farnesoid X receptor (FXR) modulators as chemical tool for gene functional analysis 47
Concepts and Optimization Strategies of Experimental Design in Continuous-Flow Processing 47
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 47
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression 47
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 47
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 46
Exploring the synthetic versatility of the Lewis acid induced decomposition reaction of a-diazo-b-hydroxy esters. The case of ethyl diazo(3-hydroxy-2-oxo-2,3-duhydro-1H-indol-3-yl)acetate 46
Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor. 46
Development of an Efficient continuous flow synthesis of glyco- and tauro-conjugated natural and semi-synthetic bile acids 46
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors 46
Effect of a UV-C automatic last-generation mobile robotic system on multi-drug resistant pathogens 46
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 45
Process for Preparing Bile Acid Derivatives 45
Molecular Doscking and High-Troughput Molecular Dynamics to Detect and Analyze the Binding Site Properties of DAF-12 Orthologs in Parasitic Nematodes 45
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 45
Design, synthesis, molecular modeling and biological activity of chenodeoxycholic acid carbamate derivatives as potent and selective FXR agonists 45
Synthesis of hydroxy lactones by selenium-mediated oxidation/cyclization of alkenoic acids under eco-flow conditions 45
Side-chain modified bile acids: chromatographic evaluation of the epimer separation 44
Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain 44
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization 44
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification 43
Building a Sulfonamide Library by Eco-friendly Flow Synthesis 43
TGR5 Activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading 42
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy 42
Bile Acid Recognition by NAPE-PLD 42
Dissecting the allosteric FXR modulation: A chemical biology approach using guggulsterone as a chemical tool 42
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration 42
HYDAMTIQ: A New, Potent PARP-1 Inhibitor with Neuroprotective Properties 41
Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3a,7a-dihydroxy-6a-ethyl-24-nor-5b-cholan-23-amine 41
TGR5 Agonists in Development. Small Molecule Approaches 41
Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs 41
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives 41
HPLC/ELSD analysis of conjugated bile acids: a way to assist flow chemistry processes 40
Totale 5.574
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Categoria #
all - tutte 36.177
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 36.177
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2019/2020374 0 0 0 0 63 12 65 9 78 100 24 23
2020/20211.165 12 68 40 66 388 72 92 30 164 35 67 131
2021/20221.327 41 228 22 69 19 24 19 430 33 96 152 194
2022/20232.281 182 367 25 198 175 250 0 88 889 11 79 17
2023/2024953 84 97 52 23 15 23 178 27 87 43 141 183
2024/2025823 53 233 99 89 349 0 0 0 0 0 0 0
Totale 7.852