IRIS - Res&Arch Institutional Research Information System - Research & Archive

GIOIELLO, ANTIMO
 Distribuzione geografica
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Continente #
NA - Nord America 5.704
AS - Asia 4.288
EU - Europa 4.025
SA - Sud America 842
Continente sconosciuto - Info sul continente non disponibili 584
AF - Africa 110
OC - Oceania 7
Totale 15.560
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Nazione #
US - Stati Uniti d'America 5.540
SG - Singapore 2.151
IT - Italia 895
IE - Irlanda 714
BR - Brasile 634
CN - Cina 551
RU - Federazione Russa 550
HK - Hong Kong 510
UA - Ucraina 398
VN - Vietnam 362
SE - Svezia 334
DE - Germania 241
FR - Francia 240
FI - Finlandia 191
GB - Regno Unito 158
IN - India 115
BD - Bangladesh 109
KR - Corea 94
CA - Canada 80
AR - Argentina 79
TR - Turchia 73
IQ - Iraq 45
JP - Giappone 43
MX - Messico 42
ES - Italia 41
PL - Polonia 40
NL - Olanda 36
ZA - Sudafrica 36
AT - Austria 35
CH - Svizzera 35
CO - Colombia 35
ID - Indonesia 33
UZ - Uzbekistan 31
PK - Pakistan 30
EC - Ecuador 28
CZ - Repubblica Ceca 27
VE - Venezuela 25
BE - Belgio 24
PH - Filippine 20
SA - Arabia Saudita 20
AE - Emirati Arabi Uniti 16
CL - Cile 15
TN - Tunisia 14
EG - Egitto 12
JM - Giamaica 12
LT - Lituania 12
MA - Marocco 12
GR - Grecia 11
MY - Malesia 10
NP - Nepal 9
PY - Paraguay 9
BG - Bulgaria 8
ET - Etiopia 8
JO - Giordania 8
LB - Libano 8
CR - Costa Rica 7
EU - Europa 6
PE - Perù 6
QA - Qatar 6
RO - Romania 6
TW - Taiwan 6
KE - Kenya 5
KZ - Kazakistan 5
OM - Oman 5
AZ - Azerbaigian 4
BO - Bolivia 4
DO - Repubblica Dominicana 4
DZ - Algeria 4
NO - Norvegia 4
PS - Palestinian Territory 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
AL - Albania 3
AU - Australia 3
DK - Danimarca 3
GT - Guatemala 3
HN - Honduras 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
SN - Senegal 3
SV - El Salvador 3
SY - Repubblica araba siriana 3
AF - Afghanistan, Repubblica islamica di 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
GD - Grenada 2
GY - Guiana 2
KG - Kirghizistan 2
MD - Moldavia 2
ME - Montenegro 2
NA - Namibia 2
NI - Nicaragua 2
RS - Serbia 2
SC - Seychelles 2
TT - Trinidad e Tobago 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BF - Burkina Faso 1
Totale 14.954
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Città #
Singapore 1.528
Dublin 714
Chandler 673
San Jose 515
Hong Kong 507
San Mateo 397
Perugia 370
Ashburn 356
Santa Clara 260
Boardman 233
Jacksonville 202
Moscow 195
Medford 169
Lauterbourg 167
Princeton 166
Beijing 124
Altamura 121
Ann Arbor 121
Wilmington 118
Los Angeles 109
Andover 99
Dong Ket 99
Lawrence 98
Seoul 90
Munich 79
Ho Chi Minh City 75
New York 65
São Paulo 60
Hanoi 58
Redmond 56
Des Moines 52
The Dalles 49
Saint Petersburg 46
Dallas 39
Orem 38
Phoenix 37
Piscataway 37
Izmir 35
Turku 35
Rome 34
Tokyo 34
Norwalk 31
Woodbridge 30
Helsinki 25
Brooklyn 23
Brussels 23
Warsaw 23
Chennai 22
Montreal 22
Chicago 21
Johannesburg 21
London 21
San Paolo di Civitate 21
Baghdad 20
Belo Horizonte 20
Shanghai 20
Buffalo 19
Atlanta 18
Denver 18
Nuremberg 18
Redwood City 18
Amsterdam 17
Brasília 17
Falls Church 17
Tashkent 17
Houston 16
Mumbai 16
Poplar 16
Stockholm 16
Manchester 15
Vienna 15
Boston 14
Toronto 14
Bologna 13
Columbus 13
Brno 12
Council Bluffs 12
Fremont 12
Lahore 12
Lappeenranta 12
Mexico City 12
Basingstoke 11
Leeds 11
Milan 11
Quito 11
Charlotte 10
Da Nang 10
Dearborn 10
Hefei 10
Kingston 10
Medellín 10
New Delhi 10
Rio de Janeiro 10
San Francisco 10
Saronno 10
Seattle 10
Spoleto 10
Ankara 9
Campinas 9
Frankfurt am Main 9
Totale 9.173
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Nome #
Discovery and Structure–Activity Relationships of Novel ssDAF-12 Receptor Modulators 173
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor 165
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 164
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells 148
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione 147
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 143
A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation 141
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 140
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 135
Vitamin E: metabolism and molecular aspects 133
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 132
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 130
Achiral-chiral two-dimensional chromatography of free amino acids in milk: A promising tool for detecting different levels of mastitis in cows 127
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 127
Analisi HPLC/ELSD di Acidi Biliari Amidati: un Approccio Efficace Per Assistere Processi Sintetici a Flusso Continuo 122
Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain 121
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 120
BF3•Et2O-Induced Decomposition of Ethyl 2-Diazo-3-hydroxy-3,3-diarylpropanoates in Acetonitrile: A Novel Approach to 2,3-Diaryl β-Enamino Ester Derivatives 119
The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology 118
Selenium catalyzed oxacyclization of alkenoic acids and alkenols 117
Development of a Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate: A Powered Entry into Steroids from Plants 117
Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors 116
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 116
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 115
BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects 114
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 113
Targeting the FXR nuclear receptor through a virtual screening approach 111
LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum 111
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency 109
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 109
Side-chain Modified Bile Acids: Chromatographic Separation of 23-Methyl Epimers 108
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 107
Improved chromatographic diastereoresolution of cyclopropyl dafachronic acid derivatives using chiral anion exchangers 107
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 106
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 106
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 105
Continuous Flow Synthesis and Enzymatic Resolution of 3-Hydroxy-ɣ-Butyrolactone (3-BHL): A Key Building Block for Synthesis and Drugs 105
Indium triflate catalyzed reaction of diisopropyl diazomethylphophonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates 104
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 103
Selective continuous flow synthesis of hydroxy lactones from alkenoic acids 103
New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compunds 102
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 102
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration 102
Multiclass screening method to detect more than fifty banned substances in bovine bile and urine 101
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives 101
Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone 100
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 100
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 100
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis 100
Application of Untargeted and Targeted Metabolomics to the Study of Liver Disease Caused by a Deficiency in HSD3B7-diagnosis and Response to Therapy 99
Development of 3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites 98
Concepts and Optimization Strategies of Experimental Design in Continuous-Flow Processing 98
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 98
HPLC/ELSD analysis of amidated bile acids: an effective and rapid way to assist continuous flow chemistry processes 97
Chromatographic separation of free dafachronic acid epimers with a novel triazole click quinidine-based chiral stationary phase 96
ATYPICAL BILE ACIDS AS CHEMICAL PROBES FOR DIAGNOSIS AND THERAPHY MONITORING OF PROGRESSIVE CHOLESTATIC LIVER DISEASE IN HSD3B7 PATIENTS 96
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 95
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy 95
Dissecting the allosteric FXR modulation: A chemical biology approach using guggulsterone as a chemical tool 95
TGR5-mediated bile acid sensing controls glucose homeostasis. 94
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 94
Chromatographic evaluation of the 25-(R,S)-methyl-bishomo-hyodeoxycholic acid epimers 93
Tandem Mass Spectrometric Determination of Atypical 3-Hydroxy-Δ5-Bile Acids in Patients with 3-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response 93
Synthesis of hydroxy lactones by selenium-mediated oxidation/cyclization of alkenoic acids under eco-flow conditions 93
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 92
Multi-Gram Scale Synthesis and Characterization of Mometasone Furoate EP Impurity C 91
Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy 90
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 89
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 89
Effect of a UV-C automatic last-generation mobile robotic system on multi-drug resistant pathogens 89
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors 88
SCALE-UP SYNTHESIS OF 3α,7α,23-TRIHYDROXY-6α-ETHYL-24-NOR-5β-CHOLAN-23-SULFATE SODIUM SALT (INT-767), A POTENT FXR/TGR5 DUAL AGONIST IN PHASE I CLINICAL STUDIES 88
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 87
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 86
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification 86
Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs 86
Flow Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles as Excipient for Spray-Drying Formulations 86
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts 85
Building a Sulfonamide Library by Eco-friendly Flow Synthesis 85
SBA15-supported nano-ruthenium catalyst for the oxidative cleavage of alkenes to aldehydes under flow conditions 85
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization 85
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 84
Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor. 83
Flow nanoprecipitation of size-controlled d-leucine nanoparticles for spray-drying formulations 83
Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications 82
Design, synthesis, molecular modeling and biological activity of chenodeoxycholic acid carbamate derivatives as potent and selective FXR agonists 82
Bile Acid Recognition by NAPE-PLD 82
The Discovery of Obeticholic Acid (Ocaliva™): First‐in‐Class FXR Agonist 82
Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23-and 6,23-Alkyl-Sobstituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5 81
TGR5 Activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading 81
New potent and selective FXR agonists: design, synthesis and modeling of norcholanylamine derivatives 81
A new divergent synthesis of dafachronic acids from bile acids 81
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives 80
Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands 79
Progress and challenges of selective Farnesoid X Receptor modulation 78
Merging Continuous Flow Technology, Photochemistry and Biocatalysis to Streamline Steroid Synthesis 77
Isocyanide chemistry enabled by continuous flow technology 77
Patented TGR5 modulators: a review (2006 - present) 77
Fast chromatographic determination of the bile salt critical micellar concentration 76
Determination of bile salt critical micellization concentration on the road to drug discovery 76
Totale 10.258
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Categoria #
all - tutte 73.654
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 73.654
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.058 0 0 22 69 19 24 19 430 33 96 152 194
2022/20232.281 182 367 25 198 175 250 0 88 889 11 79 17
2023/2024953 84 97 52 23 15 23 178 27 87 43 141 183
2024/20252.538 53 233 99 89 352 124 173 142 516 148 421 188
2025/20265.563 355 451 324 709 758 469 985 304 546 436 157 69
2026/2027430 98 191 141 0 0 0 0 0 0 0 0 0
Totale 15.560