IRIS - Res&Arch Institutional Research Information System - Research & Archive

GIOIELLO, ANTIMO
 Distribuzione geografica
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Continente #
NA - Nord America 5.426
AS - Asia 4.230
EU - Europa 3.989
SA - Sud America 826
AF - Africa 106
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 7
Totale 14.591
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Nazione #
US - Stati Uniti d'America 5.299
SG - Singapore 2.138
IT - Italia 867
IE - Irlanda 714
BR - Brasile 632
RU - Federazione Russa 550
CN - Cina 537
HK - Hong Kong 504
UA - Ucraina 398
VN - Vietnam 356
SE - Svezia 334
FR - Francia 240
DE - Germania 239
FI - Finlandia 191
GB - Regno Unito 157
IN - India 114
BD - Bangladesh 101
KR - Corea 94
AR - Argentina 75
TR - Turchia 72
CA - Canada 58
IQ - Iraq 45
JP - Giappone 43
MX - Messico 40
PL - Polonia 40
ES - Italia 38
NL - Olanda 36
ZA - Sudafrica 36
AT - Austria 35
CH - Svizzera 35
ID - Indonesia 31
UZ - Uzbekistan 31
CO - Colombia 30
PK - Pakistan 30
EC - Ecuador 26
CZ - Repubblica Ceca 25
BE - Belgio 24
VE - Venezuela 23
SA - Arabia Saudita 20
PH - Filippine 19
AE - Emirati Arabi Uniti 16
CL - Cile 15
TN - Tunisia 14
EG - Egitto 12
LT - Lituania 12
MA - Marocco 12
GR - Grecia 11
JM - Giamaica 9
NP - Nepal 9
PY - Paraguay 9
BG - Bulgaria 8
ET - Etiopia 8
JO - Giordania 8
LB - Libano 8
MY - Malesia 7
CR - Costa Rica 6
EU - Europa 6
PE - Perù 6
QA - Qatar 6
RO - Romania 6
TW - Taiwan 6
KZ - Kazakistan 5
OM - Oman 5
BO - Bolivia 4
KE - Kenya 4
NO - Norvegia 4
SK - Slovacchia (Repubblica Slovacca) 4
UY - Uruguay 4
AL - Albania 3
AU - Australia 3
AZ - Azerbaigian 3
DK - Danimarca 3
DO - Repubblica Dominicana 3
DZ - Algeria 3
NG - Nigeria 3
NZ - Nuova Zelanda 3
PS - Palestinian Territory 3
SN - Senegal 3
SY - Repubblica araba siriana 3
AF - Afghanistan, Repubblica islamica di 2
BN - Brunei Darussalam 2
BY - Bielorussia 2
GT - Guatemala 2
GY - Guiana 2
HN - Honduras 2
KG - Kirghizistan 2
MD - Moldavia 2
ME - Montenegro 2
NA - Namibia 2
RS - Serbia 2
TT - Trinidad e Tobago 2
AM - Armenia 1
AO - Angola 1
BA - Bosnia-Erzegovina 1
BB - Barbados 1
BF - Burkina Faso 1
BJ - Benin 1
BS - Bahamas 1
CG - Congo 1
DM - Dominica 1
Totale 14.567
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Città #
Singapore 1.520
Dublin 714
Chandler 673
San Jose 515
Hong Kong 501
San Mateo 397
Perugia 370
Ashburn 329
Santa Clara 238
Boardman 233
Jacksonville 201
Moscow 195
Medford 169
Lauterbourg 167
Princeton 166
Altamura 121
Ann Arbor 121
Wilmington 118
Beijing 116
Los Angeles 100
Andover 99
Dong Ket 99
Lawrence 98
Seoul 90
Munich 79
Ho Chi Minh City 74
São Paulo 60
New York 58
Hanoi 56
Redmond 56
Des Moines 52
The Dalles 49
Saint Petersburg 46
Orem 37
Dallas 35
Izmir 35
Turku 35
Tokyo 34
Rome 33
Piscataway 32
Norwalk 31
Woodbridge 30
Helsinki 25
Brussels 23
Warsaw 23
Chennai 22
Brooklyn 21
Johannesburg 21
London 21
San Paolo di Civitate 21
Baghdad 20
Montreal 20
Belo Horizonte 19
Atlanta 18
Redwood City 18
Amsterdam 17
Falls Church 17
Nuremberg 17
Shanghai 17
Tashkent 17
Brasília 16
Denver 16
Mumbai 16
Poplar 16
Stockholm 16
Chicago 15
Houston 15
Manchester 15
Vienna 15
Boston 14
Phoenix 14
Bologna 13
Columbus 13
Brno 12
Council Bluffs 12
Fremont 12
Lahore 12
Lappeenranta 12
Basingstoke 11
Leeds 11
Mexico City 11
Da Nang 10
Dearborn 10
Hefei 10
Medellín 10
New Delhi 10
Quito 10
Rio de Janeiro 10
Saronno 10
Seattle 10
Spoleto 10
Campinas 9
Charlotte 9
Frankfurt am Main 9
Macerata 9
Porto Alegre 9
State College 9
Addis Ababa 8
Ankara 8
Buffalo 8
Totale 9.004
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Nome #
Discovery and Structure–Activity Relationships of Novel ssDAF-12 Receptor Modulators 170
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 161
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor 157
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells 146
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione 146
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 141
A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation 140
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 139
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 134
Vitamin E: metabolism and molecular aspects 130
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 128
Achiral-chiral two-dimensional chromatography of free amino acids in milk: A promising tool for detecting different levels of mastitis in cows 127
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 126
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 124
Analisi HPLC/ELSD di Acidi Biliari Amidati: un Approccio Efficace Per Assistere Processi Sintetici a Flusso Continuo 121
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 119
The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology 117
BF3•Et2O-Induced Decomposition of Ethyl 2-Diazo-3-hydroxy-3,3-diarylpropanoates in Acetonitrile: A Novel Approach to 2,3-Diaryl β-Enamino Ester Derivatives 116
Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain 116
Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors 115
Development of a Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate: A Powered Entry into Steroids from Plants 115
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 114
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 113
Selenium catalyzed oxacyclization of alkenoic acids and alkenols 113
BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects 111
Targeting the FXR nuclear receptor through a virtual screening approach 109
LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum 109
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 109
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 108
Improved chromatographic diastereoresolution of cyclopropyl dafachronic acid derivatives using chiral anion exchangers 106
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 105
Side-chain Modified Bile Acids: Chromatographic Separation of 23-Methyl Epimers 104
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 104
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 103
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 103
Indium triflate catalyzed reaction of diisopropyl diazomethylphophonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates 102
Continuous Flow Synthesis and Enzymatic Resolution of 3-Hydroxy-ɣ-Butyrolactone (3-BHL): A Key Building Block for Synthesis and Drugs 102
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 102
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency 101
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 101
Multiclass screening method to detect more than fifty banned substances in bovine bile and urine 100
New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compunds 99
Application of Untargeted and Targeted Metabolomics to the Study of Liver Disease Caused by a Deficiency in HSD3B7-diagnosis and Response to Therapy 99
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 99
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration 99
Selective continuous flow synthesis of hydroxy lactones from alkenoic acids 99
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 98
Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone 97
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives 97
Development of 3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites 96
HPLC/ELSD analysis of amidated bile acids: an effective and rapid way to assist continuous flow chemistry processes 96
Concepts and Optimization Strategies of Experimental Design in Continuous-Flow Processing 96
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 96
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis 96
Chromatographic separation of free dafachronic acid epimers with a novel triazole click quinidine-based chiral stationary phase 94
ATYPICAL BILE ACIDS AS CHEMICAL PROBES FOR DIAGNOSIS AND THERAPHY MONITORING OF PROGRESSIVE CHOLESTATIC LIVER DISEASE IN HSD3B7 PATIENTS 94
Dissecting the allosteric FXR modulation: A chemical biology approach using guggulsterone as a chemical tool 93
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 92
Chromatographic evaluation of the 25-(R,S)-methyl-bishomo-hyodeoxycholic acid epimers 92
Tandem Mass Spectrometric Determination of Atypical 3-Hydroxy-Δ5-Bile Acids in Patients with 3-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response 92
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy 92
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 91
Synthesis of hydroxy lactones by selenium-mediated oxidation/cyclization of alkenoic acids under eco-flow conditions 91
Effect of a UV-C automatic last-generation mobile robotic system on multi-drug resistant pathogens 89
TGR5-mediated bile acid sensing controls glucose homeostasis. 88
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors 88
Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy 88
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 87
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 87
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 86
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 86
SCALE-UP SYNTHESIS OF 3α,7α,23-TRIHYDROXY-6α-ETHYL-24-NOR-5β-CHOLAN-23-SULFATE SODIUM SALT (INT-767), A POTENT FXR/TGR5 DUAL AGONIST IN PHASE I CLINICAL STUDIES 86
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification 85
Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs 85
Flow Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles as Excipient for Spray-Drying Formulations 84
Multi-Gram Scale Synthesis and Characterization of Mometasone Furoate EP Impurity C 84
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 83
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 83
SBA15-supported nano-ruthenium catalyst for the oxidative cleavage of alkenes to aldehydes under flow conditions 83
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization 83
Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor. 82
Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications 81
New potent and selective FXR agonists: design, synthesis and modeling of norcholanylamine derivatives 81
Bile Acid Recognition by NAPE-PLD 81
Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23-and 6,23-Alkyl-Sobstituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5 80
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts 80
A new divergent synthesis of dafachronic acids from bile acids 80
Design, synthesis, molecular modeling and biological activity of chenodeoxycholic acid carbamate derivatives as potent and selective FXR agonists 80
TGR5 Activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading 79
Building a Sulfonamide Library by Eco-friendly Flow Synthesis 79
Flow nanoprecipitation of size-controlled d-leucine nanoparticles for spray-drying formulations 79
Progress and challenges of selective Farnesoid X Receptor modulation 77
Synthesis and biological activity of cyclopropyl Δ7-dafachronic acids as DAF-12 receptor ligands 77
Chemical exploration of TGR5 functional hot-spots: Synthesis and structure-activity relationships of C7- and C23-Substituted cholic acid derivatives 76
Fast chromatographic determination of the bile salt critical micellar concentration 76
Determination of bile salt critical micellization concentration on the road to drug discovery 76
The Discovery of Obeticholic Acid (Ocaliva™): First‐in‐Class FXR Agonist 76
Patented TGR5 modulators: a review (2006 - present) 76
Isocyanide chemistry enabled by continuous flow technology 75
HYDAMTIQ: A New, Potent PARP-1 Inhibitor with Neuroprotective Properties 75
Totale 10.026
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Categoria #
all - tutte 69.361
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 69.361
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2021/20221.327 41 228 22 69 19 24 19 430 33 96 152 194
2022/20232.281 182 367 25 198 175 250 0 88 889 11 79 17
2023/2024953 84 97 52 23 15 23 178 27 87 43 141 183
2024/20252.538 53 233 99 89 352 124 173 142 516 148 421 188
2025/20265.563 355 451 324 709 758 469 985 304 546 436 157 69
2026/202737 37 0 0 0 0 0 0 0 0 0 0 0
Totale 15.167