IRIS - Res&Arch Institutional Research Information System - Research & Archive

GIOIELLO, ANTIMO
 Distribuzione geografica
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Continente #
NA - Nord America 4.561
EU - Europa 3.485
AS - Asia 3.165
SA - Sud America 677
AF - Africa 63
Continente sconosciuto - Info sul continente non disponibili 7
OC - Oceania 7
Totale 11.965
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Nazione #
US - Stati Uniti d'America 4.471
SG - Singapore 1.554
IT - Italia 793
IE - Irlanda 708
BR - Brasile 568
HK - Hong Kong 466
CN - Cina 463
RU - Federazione Russa 396
UA - Ucraina 394
SE - Svezia 334
VN - Vietnam 299
DE - Germania 232
FI - Finlandia 186
GB - Regno Unito 133
KR - Corea 93
FR - Francia 58
IN - India 54
AR - Argentina 51
TR - Turchia 49
CA - Canada 44
PL - Polonia 40
JP - Giappone 37
CH - Svizzera 35
MX - Messico 32
AT - Austria 30
ZA - Sudafrica 28
ES - Italia 27
NL - Olanda 26
BE - Belgio 23
BD - Bangladesh 22
CZ - Repubblica Ceca 21
UZ - Uzbekistan 19
EC - Ecuador 17
PK - Pakistan 17
ID - Indonesia 14
IQ - Iraq 13
AE - Emirati Arabi Uniti 11
CO - Colombia 10
GR - Grecia 10
MA - Marocco 10
CL - Cile 9
LT - Lituania 9
BG - Bulgaria 7
EG - Egitto 7
LB - Libano 7
VE - Venezuela 7
EU - Europa 6
NP - Nepal 6
KZ - Kazakistan 5
RO - Romania 5
SA - Arabia Saudita 5
TN - Tunisia 5
TW - Taiwan 5
PY - Paraguay 4
AU - Australia 3
BO - Bolivia 3
DO - Repubblica Dominicana 3
NO - Norvegia 3
NZ - Nuova Zelanda 3
OM - Oman 3
PE - Perù 3
SK - Slovacchia (Repubblica Slovacca) 3
UY - Uruguay 3
AF - Afghanistan, Repubblica islamica di 2
BN - Brunei Darussalam 2
CR - Costa Rica 2
DK - Danimarca 2
GT - Guatemala 2
GY - Guiana 2
JM - Giamaica 2
JO - Giordania 2
KE - Kenya 2
ME - Montenegro 2
NA - Namibia 2
PS - Palestinian Territory 2
QA - Qatar 2
RS - Serbia 2
SY - Repubblica araba siriana 2
AM - Armenia 1
AZ - Azerbaigian 1
BB - Barbados 1
BS - Bahamas 1
CG - Congo 1
DM - Dominica 1
DZ - Algeria 1
ET - Etiopia 1
GA - Gabon 1
HN - Honduras 1
HU - Ungheria 1
IL - Israele 1
IS - Islanda 1
KG - Kirghizistan 1
KH - Cambogia 1
LV - Lettonia 1
MD - Moldavia 1
MM - Myanmar 1
MN - Mongolia 1
MU - Mauritius 1
NE - Niger 1
NG - Nigeria 1
Totale 11.954
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Città #
Singapore 996
Dublin 708
Chandler 673
Hong Kong 463
San Mateo 397
Perugia 353
Boardman 233
Santa Clara 223
Ashburn 220
Jacksonville 201
Medford 169
Princeton 166
Moscow 139
Altamura 121
Ann Arbor 121
Wilmington 118
Andover 99
Beijing 99
Dong Ket 99
Lawrence 98
Los Angeles 94
Seoul 90
Munich 79
Ho Chi Minh City 60
Redmond 56
New York 52
São Paulo 52
Des Moines 51
Hanoi 46
Saint Petersburg 46
Turku 36
Izmir 33
Dallas 32
Piscataway 32
The Dalles 32
Norwalk 31
Tokyo 30
Woodbridge 30
Rome 25
Brussels 23
Warsaw 23
Brooklyn 21
Johannesburg 21
San Paolo di Civitate 21
London 20
Helsinki 19
Belo Horizonte 18
Redwood City 18
Denver 17
Falls Church 17
Montreal 17
Atlanta 16
Nuremberg 16
Poplar 16
Stockholm 16
Boston 14
Brasília 14
Shanghai 14
Bologna 13
Orem 13
Brno 12
Chicago 12
Columbus 12
Fremont 12
Houston 12
Lappeenranta 12
Manchester 12
Vienna 12
Leeds 11
Mumbai 11
Phoenix 11
Amsterdam 10
Chennai 10
Dearborn 10
Hefei 10
Saronno 10
Spoleto 10
Ankara 9
Campinas 9
Macerata 9
Rio de Janeiro 9
Seattle 9
State College 9
Haiphong 8
Porto Alegre 8
San Francisco 8
Tashkent 8
Charlotte 7
Curitiba 7
Da Nang 7
Frankfurt Am Main 7
Guangzhou 7
Lahore 7
Mexico City 7
New Delhi 7
Ninh Bình 7
Querétaro 7
Arroyo de la Encomienda 6
Bắc Ninh 6
Calgary 6
Totale 7.333
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Nome #
Computational studies in enantioselective liquid chromatography: Forty years of evolution in docking- and molecular dynamics-based simulations 146
SARS-CoV2 infection impairs the metabolism and redox function of cellular glutathione 131
Garcinoic Acid Is a Natural and Selective Agonist of Pregnane X Receptor 130
Selected cholesterol biosynthesis inhibitors produce accumulation of the intermediate FF-MAS that targets nucleus and activates LXRα in HepG2 cells 122
9. The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR) 120
Avicholic Acid: A Primary Bile Acid from Birds on the Route to Potent and Selective TGR5 Ligands 117
Analisi HPLC/ELSD di Acidi Biliari Amidati: un Approccio Efficace Per Assistere Processi Sintetici a Flusso Continuo 111
Achiral-chiral two-dimensional chromatography of free amino acids in milk: A promising tool for detecting different levels of mastitis in cows 111
Vitamin E: metabolism and molecular aspects 111
Continuous Flow Synthesis of Thieno[2,3-c]isoquinolin-5(4H)-one Scaffold: A Valuable Source of PARP-1 Inhibitors 109
D-leucine microparticles as an excipient to improve the aerosolization performances of dry powders for inhalation 106
Molecular field analysis and 3D-quantitative structure-activity relationship study (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5. 104
Integrated Fragment-Based Approaches on the Route to Novel IDO1 Modulators 102
Discovery and Structure–Activity Relationships of Novel ssDAF-12 Receptor Modulators 100
Cyclopropyl Dafachronic Acid Stereoisomers as Conformationally Constrained DAF-12 Ligands 100
A streamlined synthesis of the neurosteroid 3β-methoxypregnenolone assisted by a statistical experimental design and automation 100
Selenium catalyzed oxacyclization of alkenoic acids and alkenols 99
Novel Potent and Selective Bile Acid Derivatives as TGR5 Agonists: Biological Screening, Structure-Activity Relationships and Molecular Modeling Studies 97
Beyond Bile Acids: Targeting Farnesoid X Receptor (FXR) with Natural and Synthetic Ligands 97
Development of a Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate: A Powered Entry into Steroids from Plants 97
Enantioselective HPLC analysis to assist the chemical exploration of chiral imidazolines 97
Discovery of 6α-Ethyl-23(S)-methyl-cholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity 95
The Medicinal Chemistry in the Era of Machines and Automation: Recent Advances in Continuous Flow Technology 95
Side-chain Modified Bile Acids: Chromatographic Separation of 23-Methyl Epimers 94
Targeting the FXR nuclear receptor through a virtual screening approach 94
Side chain modified HDCA derivatives: synthesis, CMC determination and molecular modelling studies. 94
BF3•Et2O-Induced Decomposition of Ethyl 2-Diazo-3-hydroxy-3,3-diarylpropanoates in Acetonitrile: A Novel Approach to 2,3-Diaryl β-Enamino Ester Derivatives 93
BF3·Et2O-Promoted Decomposition of Cyclic α-Diazo-β-Hydroxy Ketones: Novel Insights into Mechanistic Aspects 92
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor: Molecular Determinants for Bile Acid Binding and Receptor Modulation 91
Improved chromatographic diastereoresolution of cyclopropyl dafachronic acid derivatives using chiral anion exchangers 91
LC-MS/MS assay for the simultaneous determination of tocopherols, polyunsaturated fatty acids and their metabolites in human plasma and serum 91
Garcinoic acid prevents β-amyloid (Aβ) deposition in the mouse brain 91
The Stone Guest: How Does pH Affect Binding Properties of PD-1/PD-L1 Inhibitors? 91
New one-pot synthesis of pyrazole-5-carboxylates by 1,3-dipole cycloadditions of ethyl diazoacetate with α-methylene carbonyl compunds 90
Indium triflate catalyzed reaction of diisopropyl diazomethylphophonate with imines as a new approach to cis- and trans-aziridine-2-phosphonates 90
Avicholic acid: a lead compound from birds on the route to potent TGR5 modulators 90
Continuous Flow Synthesis and Enzymatic Resolution of 3-Hydroxy-ɣ-Butyrolactone (3-BHL): A Key Building Block for Synthesis and Drugs 90
Selective continuous flow synthesis of hydroxy lactones from alkenoic acids 90
Chromatographic hydrophobicity index: a high-throughput tool to estimate the critical micellar concentration of bile acids 87
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy. 87
Unravelling the molecular basis for DAF-12 activation: diastereoselective synthesis and SAR studies of dafachronic acid derivatives. 85
Exploiting Chemical Toolboxes for the Expedited Generation of Tetracyclic Quinolines as a Novel Class of PXR Agonists 83
Chromatographic separation of free dafachronic acid epimers with a novel triazole click quinidine-based chiral stationary phase 82
Application of Untargeted and Targeted Metabolomics to the Study of Liver Disease Caused by a Deficiency in HSD3B7-diagnosis and Response to Therapy 82
Tandem Mass Spectrometric Determination of Atypical 3-Hydroxy-Δ5-Bile Acids in Patients with 3-Hydroxy-Δ5-C27-Steroid Oxidoreductase Deficiency: Application to Diagnosis and Monitoring of Bile Acid Therapeutic Response 82
ATYPICAL BILE ACIDS AS CHEMICAL PROBES FOR DIAGNOSIS AND THERAPHY MONITORING OF PROGRESSIVE CHOLESTATIC LIVER DISEASE IN HSD3B7 PATIENTS 82
Investigating the allosteric reverse signalling of PARP inhibitors with microsecond molecular dynamic simulations and fluorescence anisotropy 81
Concepts and Optimization Strategies of Experimental Design in Continuous-Flow Processing 81
Integrating Multicomponent Flow Synthesis and Computational Approaches for the Generation of a Tetrahydroquinoline Compound Based Library 81
Multiclass screening method to detect more than fifty banned substances in bovine bile and urine 81
HPLC/ELSD analysis of amidated bile acids: an effective and rapid way to assist continuous flow chemistry processes 80
The Janus-faced nature of IDO1 in infectious diseases: Challenges and therapeutic opportunities 80
Discovery of 3α,7α,11β-Trihydroxy-6α-ethyl-5β-cholan-24-oic Acid (TC-100), a Novel Bile Acid as Potent and Highly Selective FXR Agonist for Enterohepatic Disorders 79
Bile Acids Signal via TGR5 to Activate Intestinal Stem Cells and Epithelial Regeneration 79
Novel stereoselective synthesis and chromatographic evaluation of E-guggulsterone 77
Synthesis of hydroxy lactones by selenium-mediated oxidation/cyclization of alkenoic acids under eco-flow conditions 77
Back door modulation of the farnesoid X receptor: design, synthesis, and biological evaluation of a series of side chain modified chenodeoxycholic acid derivatives. 77
Integrating experimental and computational techniques to study chromatographic enantioresolutions of chiral tetrahydroindazole derivatives 77
Derived chromatographic indices as effective tools to study the self-aggregation process of bile acids 76
Discovery and characterization of novel potent PARP-1 inhibitors endowed with neuroprotective properties: From TIQ-A to HYDAMTIQ 76
Recent advances in urea- and thiourea-containing compounds: focus on innovative approaches in medicinal chemistry and organic synthesis 76
Effect of a UV-C automatic last-generation mobile robotic system on multi-drug resistant pathogens 75
Development of 3α, 7α-dihydroxy-6α-ethyl-24-nor-5β-cholan-23-sulfate sodium salt (INT-767): Process optimization, synthesis and characterization of metabolites 74
Domino synthesis of 5-aminoimidazoles from Strecker multicomponent adducts via ytterbium-promoted isocyanide insertion/5-exo-dig cyclization 74
Chromatographic evaluation of the 25-(R,S)-methyl-bishomo-hyodeoxycholic acid epimers 73
Targeting the FXR Nuclear Receptor through a Virtual Screening Approach 73
Bile Acid Recognition by NAPE-PLD 73
Concepts and Molecular Aspects in the Polypharmacology of PARP-1 Inhibitors 72
Potential Therapeutic Applications of Farnesoid X Receptor (FXR) Modulators 71
Turning a Tumor Microenvironment Pitfall into Opportunity: Discovery of Benzamidoxime as PD-L1 Ligand with pH-Dependent Potency 70
Molecular Dynamics Simulation of the Ligand Binding Domain of Farnesoid X Receptor (FXR). Insights into Helix-12 Stability and Coactivator Peptide Stabilization in Response to Agonist Binding 70
Continuous flow synthesis and scale-up of glycine- and taurine-conjugated bile salts 70
New potent and selective FXR agonists: design, synthesis and modeling of norcholanylamine derivatives 70
Flow Nanoprecipitation of Size-Controlled D-Leucine Nanoparticles as Excipient for Spray-Drying Formulations 70
Dissecting the allosteric FXR modulation: A chemical biology approach using guggulsterone as a chemical tool 70
Nongenomic Actions of Bile Acids. Synthesis and Preliminary Characterization of 23-and 6,23-Alkyl-Sobstituted Bile Acid Derivatives as Selective Modulators for the G-Protein Coupled Receptor TGR5 69
Continuous Flow Synthesis of 16-Dehydropregnenolone Acetate, a Key Synthon for Natural Steroids and Drugs 69
Multi-Gram Scale Synthesis and Characterization of Mometasone Furoate EP Impurity C 69
Fast chromatographic determination of the bile salt critical micellar concentration 68
Molecular field analysis and quantitative structure-activity studies (MFA 3D-QSAR) unveil novel features of bile acid recognition at TGR5 receptor. 68
A new divergent synthesis of dafachronic acids from bile acids 68
Bile Acid Derivatives as Ligands of the Farnesoid X Receptor. Synthesis, Evaluation, and Structure Activity Relationship of a Series of Body and Side Chain Modified Analogs of Chenodeoxycholic Acid 68
Progress and challenges of selective Farnesoid X Receptor modulation 68
Synthesis, physicochemical properties, and biological activity of bile acids 3-glucuronides: Novel insights into bile acid signalling and detoxification 67
Flow nanoprecipitation of size-controlled d-leucine nanoparticles for spray-drying formulations 67
SBA15-supported nano-ruthenium catalyst for the oxidative cleavage of alkenes to aldehydes under flow conditions 67
SCALE-UP SYNTHESIS OF 3α,7α,23-TRIHYDROXY-6α-ETHYL-24-NOR-5β-CHOLAN-23-SULFATE SODIUM SALT (INT-767), A POTENT FXR/TGR5 DUAL AGONIST IN PHASE I CLINICAL STUDIES 66
Building a Sulfonamide Library by Eco-friendly Flow Synthesis 66
The glucocorticoid mometasone furoate is a novel FXR ligand that decreases inflammatory but not metabolic gene expression 66
TGR5 Activation inhibits atherosclerosis by reducing macrophage inflammation and lipid loading 65
Novel body modified bile acid derivatives as TGR5 modulators 65
Design, synthesis, molecular modeling and biological activity of chenodeoxycholic acid carbamate derivatives as potent and selective FXR agonists 65
Endoplasmic reticulum stress and NF-kB activation in SARS-CoV-2 infected cells and their response to antiviral therapy 65
Divergent and stereoselective synthesis of dafachronic acids 63
Mesofluidic Flash Nanoprecipitation of D-Leucine Particles as Excipient in Powders for Inhalation 63
TGR5-mediated bile acid sensing controls glucose homeostasis. 62
The Discovery of Obeticholic Acid (Ocaliva™): First‐in‐Class FXR Agonist 62
HPLC/ELSD analysis of conjugated bile acids: a way to assist flow chemistry processes 61
Continuous Flow Singlet Oxygen Photooxygenation Reactions: Recent Advances and Applications 60
Extending SAR of bile acids as FXR ligands: Discovery of 23-N-(carbocinnamyloxy)-3a,7a-dihydroxy-6a-ethyl-24-nor-5b-cholan-23-amine 60
Totale 8.359
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Categoria #
all - tutte 59.680
article - articoli 0
book - libri 0
conference - conferenze 0
curatela - curatele 0
other - altro 0
patent - brevetti 0
selected - selezionate 0
volume - volumi 0
Totale 59.680
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Totale Lug Ago Sett Ott Nov Dic Gen Feb Mar Apr Mag Giu
2020/2021591 0 0 0 0 0 72 92 30 164 35 67 131
2021/20221.327 41 228 22 69 19 24 19 430 33 96 152 194
2022/20232.281 182 367 25 198 175 250 0 88 889 11 79 17
2023/2024953 84 97 52 23 15 23 178 27 87 43 141 183
2024/20252.545 53 233 99 89 352 124 173 142 517 149 425 189
2025/20262.960 357 454 324 717 763 345 0 0 0 0 0 0
Totale 12.534